Approaching the challenges of MKK3/p38delta MAPK targeting for therapeutic purpose in colorectal cancer

Approaching the challenges of MKK3/p38delta MAPK targeting for therapeutic purpose in colorectal cancer

Abstract MKK3 is a member of the dual specificity kinase group specific upstream activator of p38 MAPK proteins. We originally identified MKK3 as mutant p53 (mutp53) gain-of-function (GOF) upregulated target gene in different tumor models. To deeply investigate the MKK3 functions in cancer, taking a...

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Bibliographic Details
Main Authors: Lorenzo Stramucci, Gianluca Bossi
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal Cancer
MKK3 / p38 MAPK signalling
p38 delta MAPK
Chemotherapy
Target therapy
Combined treatments
Online Access:https://doi.org/10.1186/s13046-019-1513-4

Internet

https://doi.org/10.1186/s13046-019-1513-4

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