A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization...

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Bibliographic Details
Main Authors: Sébastien Thériault, Nathalie Gaudreault, Maxime Lamontagne, Mickael Rosa, Marie-Chloé Boulanger, David Messika-Zeitoun, Marie-Annick Clavel, Romain Capoulade, François Dagenais, Philippe Pibarot, Patrick Mathieu, Yohan Bossé
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03260-6

Internet

https://doi.org/10.1038/s41467-018-03260-6

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