p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress

Abstract Stem and progenitor cells are the main mediators of tissue renewal and repair, both under homeostatic conditions and in response to physiological stress and injury. Hematopoietic system is responsible for the regeneration of blood and immune cells and is maintained by bone marrow-resident h...

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Bibliographic Details
Main Authors: Lin Tze Tung, HanChen Wang, Jad I. Belle, Jessica C. Petrov, David Langlais, Anastasia Nijnik
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04202-9