Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained by Polycomb Repressive Complexes (PRCs). Her...

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Bibliographic Details
Main Authors: Zaijun Ma, Hui Wang, Yuping Cai, Han Wang, Kongyan Niu, Xiaofen Wu, Huanhuan Ma, Yun Yang, Wenhua Tong, Feng Liu, Zhandong Liu, Yaoyang Zhang, Rui Liu, Zheng-Jiang Zhu, Nan Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
epigenetic drift
H3K27me3
glycolysis
aging
metabolic health
longevity
Online Access:https://elifesciences.org/articles/35368

Internet

https://elifesciences.org/articles/35368

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