Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination
Inflammatory diseases: Putting on the brakes Acetate, a short-chain fatty acid, reduces activation of the NLRP3 inflammasome, a multiprotein complex that mediates inflammation. Acetate is produced by gut bacteria and can stimulate the synthesis of fat. High levels of acetate have been associated wit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-07-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0276-5 |