Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination
Inflammatory diseases: Putting on the brakes Acetate, a short-chain fatty acid, reduces activation of the NLRP3 inflammasome, a multiprotein complex that mediates inflammation. Acetate is produced by gut bacteria and can stimulate the synthesis of fat. High levels of acetate have been associated wit...
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2019-07-01
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doaj-9cf7c83a28514dd3be7ef9d0c3d602b62020-12-08T13:50:25ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-07-0151711310.1038/s12276-019-0276-5Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitinationMengda Xu0Zhengyu Jiang1Changli Wang2Na Li3Lulong Bo4Yanping Zha5Jinjun Bian6Yan Zhang7Xiaoming Deng8Faculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityFaculty of Anesthesiology, Changhai Hospital, Second Military Medical UniversityInflammatory diseases: Putting on the brakes Acetate, a short-chain fatty acid, reduces activation of the NLRP3 inflammasome, a multiprotein complex that mediates inflammation. Acetate is produced by gut bacteria and can stimulate the synthesis of fat. High levels of acetate have been associated with diabetes, heart failure and tumor growth, but its effects on the immune system are largely unknown. A study led by Xiaoming Deng and Yan Zhang at the Second Military Medical University in Shanghai, China, shows that acetate has protective effects in mouse models of peritoneal and systemic inflammation and does not cause significant toxicity. Acetate suppresses inflammation by triggering a signaling pathway that reduces the activity of the NLRP3 inflammasome and leads to its degradation. These findings highlight a potential new approach for treating inflammatory diseases.https://doi.org/10.1038/s12276-019-0276-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mengda Xu Zhengyu Jiang Changli Wang Na Li Lulong Bo Yanping Zha Jinjun Bian Yan Zhang Xiaoming Deng |
spellingShingle |
Mengda Xu Zhengyu Jiang Changli Wang Na Li Lulong Bo Yanping Zha Jinjun Bian Yan Zhang Xiaoming Deng Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination Experimental and Molecular Medicine |
author_facet |
Mengda Xu Zhengyu Jiang Changli Wang Na Li Lulong Bo Yanping Zha Jinjun Bian Yan Zhang Xiaoming Deng |
author_sort |
Mengda Xu |
title |
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination |
title_short |
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination |
title_full |
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination |
title_fullStr |
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination |
title_full_unstemmed |
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination |
title_sort |
acetate attenuates inflammasome activation through gpr43-mediated ca2+-dependent nlrp3 ubiquitination |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2019-07-01 |
description |
Inflammatory diseases: Putting on the brakes Acetate, a short-chain fatty acid, reduces activation of the NLRP3 inflammasome, a multiprotein complex that mediates inflammation. Acetate is produced by gut bacteria and can stimulate the synthesis of fat. High levels of acetate have been associated with diabetes, heart failure and tumor growth, but its effects on the immune system are largely unknown. A study led by Xiaoming Deng and Yan Zhang at the Second Military Medical University in Shanghai, China, shows that acetate has protective effects in mouse models of peritoneal and systemic inflammation and does not cause significant toxicity. Acetate suppresses inflammation by triggering a signaling pathway that reduces the activity of the NLRP3 inflammasome and leads to its degradation. These findings highlight a potential new approach for treating inflammatory diseases. |
url |
https://doi.org/10.1038/s12276-019-0276-5 |
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