Enhancing the bioconversion of phytosterols to steroidal intermediates by the deficiency of kasB in the cell wall synthesis of Mycobacterium neoaurum

Abstract Background The bioconversion of phytosterols into high value-added steroidal intermediates, including the 9α-hydroxy-4-androstene-3,17-dione (9-OHAD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC), is the cornerstone in steroid pharmaceutical industry. However, the low transportation e...

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Bibliographic Details
Main Authors: Liang-Bin Xiong, Hao-Hao Liu, Ming Zhao, Yong-Jun Liu, Lu Song, Zhi-Yong Xie, Yi-Xin Xu, Feng-Qing Wang, Dong-Zhi Wei
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Microbial Cell Factories
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12934-020-01335-y