Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression

Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression

Background: Despite recent improvement in the treatment of malignant melanoma by immune-checkpoint inhibitors, the disease can progress due to an immunosuppressive tumor microenvironment (TME) mainly represented by myeloid-derived suppressor cells (MDSC). However, the relative contribution of the po...

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Bibliographic Details
Main Authors: Christopher Groth, Ludovica Arpinati, Merav E. Shaul, Nina Winkler, Klara Diester, Nicolas Gengenbacher, Rebekka Weber, Ihor Arkhypov, Samantha Lasser, Vera Petrova, Hellmut G. Augustin, Peter Altevogt, Jochen Utikal, Zvi G. Fridlender, Viktor Umansky
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
PMN-MDSC
CXCR2
CXCL1
immunosuppression
melanoma
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/13/4/726

Internet

https://www.mdpi.com/2072-6694/13/4/726

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