Preparation of Enantiomeric β-(2′,5′-Dimethylphenyl)Bromolactones, Their Antiproliferative Activity and Effect on Biological Membranes

Preparation of Enantiomeric β-(2′,5′-Dimethylphenyl)Bromolactones, Their Antiproliferative Activity and Effect on Biological Membranes

Three novel enantiomeric pairs of bromolactones possesing a 2,5-dimethylphenyl substituent at the &#946;-position of the lactone ring have been synthesized from corresponding enantiomeric (<i>E</i>)-3-(2&#8242;,5&#8242;-dimethylphenyl)hex-4-enoic acids (<b>4</b>)...

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Bibliographic Details
Main Authors: Witold Gładkowski, Aleksandra Włoch, Aleksandra Pawlak, Angelika Sysak, Agata Białońska, Marcelina Mazur, Paweł Mituła, Gabriela Maciejewska, Bożena Obmińska-Mrukowicz, Halina Kleszczyńska
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
lactones
bromolactonization
absolute configurations
antiproliferative activity
hemolytic activity
erythrocytes
biological membranes
Online Access:https://www.mdpi.com/1420-3049/23/11/3035

Internet

https://www.mdpi.com/1420-3049/23/11/3035

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