Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

The polarization of nascent embryonic fields and the endowment of cells with organizer properties are key to initiation of vertebrate organogenesis. One such event is antero-posterior (AP) polarization of early limb buds and activation of morphogenetic Sonic Hedgehog (SHH) signaling in the posterior...

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Bibliographic Details
Main Authors: Antonella Galli, Dimitri Robay, Marco Osterwalder, Xiaozhong Bao, Jean-Denis Bénazet, Muhammad Tariq, Renato Paro, Susan Mackem, Rolf Zeller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2851570?pdf=render

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http://europepmc.org/articles/PMC2851570?pdf=render

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