Desensitization of human breast progenitors by a transient exposure to pregnancy levels of estrogen

Abstract Full term pregnancy at an early age is the only factor known to consistently protect against breast cancer. Because hormone receptor positive progenitors in the human breast relay endocrine signaling, we here sought to determine whether an experimental mimicry of the third trimester surge o...

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Bibliographic Details
Main Authors: Lone Rønnov-Jessen, Jiyoung Kim, Nadine Goldhammer, Marie Christine Klitgaard, Martynas Smicius, Marc Baker Bechmann, René Villadsen, Ole William Petersen
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96785-8