Epigenetic Silencing of Ubiquitin Specific Protease 4 by Snail1 Contributes to Macrophage-Dependent Inflammation and Therapeutic Resistance in Lung Cancer

Epigenetic Silencing of Ubiquitin Specific Protease 4 by Snail1 Contributes to Macrophage-Dependent Inflammation and Therapeutic Resistance in Lung Cancer

There is a positive feedback loop driving tumorigenesis and tumor growth through coordinated regulation of epigenetics, inflammation, and stemness. Nevertheless, the molecular mechanism linking these processes is not well understood. In this study, we analyzed the correlation of de-ubiquitinases (DU...

Full description

Bibliographic Details
Main Authors: Chao-Yang Lai, Da-Wei Yeh, Chih-Hao Lu, Yi-Ling Liu, Yu-Chen Chuang, Jhen-Wei Ruan, Cheng-Yuan Kao, Li-Rung Huang, Tsung-Hsien Chuang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
deubiquitination
snail1
inflammation
stemness
epigenetic regulation
Online Access:https://www.mdpi.com/2072-6694/12/1/148

Internet

https://www.mdpi.com/2072-6694/12/1/148

Similar Items