Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.

The spatiotemporal distribution of drugs in the inner ear cannot be precisely evaluated because of its small area and complex structure. In the present study, we used hyaluronic acid (HA)-dispersed luciferin to image transgenic mice and to determine the effect of HA on controlled drug delivery to th...

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Main Authors: Yozo Inagaki, Masato Fujioka, Sho Kanzaki, Kotaro Watanabe, Naoki Oishi, Go Itakura, Akimasa Yasuda, Shinsuke Shibata, Masaya Nakamura, Hirotaka James Okano, Hideyuki Okano, Kaoru Ogawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4839654?pdf=render