Sex-Mediated Differences in LPS Induced Alterations of TNFα, IL-10 Expression, and Prostaglandin Synthesis in Primary Astrocytes

Sex-Mediated Differences in LPS Induced Alterations of TNFα, IL-10 Expression, and Prostaglandin Synthesis in Primary Astrocytes

Although many neurological and psychiatric disorders reveal clear sex-dependent variations, the molecular mechanism of this process is not clear enough. Astrocytes are involved in the response of neural tissue to injury and inflammation, produce steroid hormones, and sense steroid presence. To explo...

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Bibliographic Details
Main Authors: Dmitry V. Chistyakov, Nadezda V. Azbukina, Alina A. Astakhova, Sergei V. Goriainov, Viktor V. Chistyakov, Marina G. Sergeeva
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
sex difference
neuroinflammation
COX-2
3β-HSD
astrocytes
trilostane
LPS
TLR4
IL-10
TNFα
Online Access:http://www.mdpi.com/1422-0067/19/9/2793

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http://www.mdpi.com/1422-0067/19/9/2793

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