Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages

Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages

Chemotherapy is commonly used as a major therapeutic option for breast cancer treatment, but its efficacy is often diminished by disruption of patient’s anti-tumor immunity. Chemotherapy-generated tumor cell debris could hijack accumulated tumor-associated macrophages (TAMs), provoking tumor recurre...

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Bibliographic Details
Main Authors: Seung Hyeon Kim, Soma Saeidi, Xiancai Zhong, Shin-Young Gwak, Ishrat Aklima Muna, Sin-Aye Park, Seong Hoon Kim, Hye-Kyung Na, Yeonsoo Joe, Hun Taeg Chung, Kyoung-Eun Kim, Wonshik Han, Young-Joon Surh
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Breast cancer
Chemotherapy
Tumor-associated macrophages
Phagocytosis
Tumor cell debris
Heme oxygenase-1
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301445

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http://www.sciencedirect.com/science/article/pii/S1476558620301445

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