Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis.

Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis.

In multiple sclerosis (MS) autoaggressive T effector cells (Teff) are not efficiently controlled by regulatory T cells (Treg) but the underlying mechanisms are incompletely understood. Proinflammatory cytokines are key factors facilitating Teff activity in chronic inflammation. Here we investigated...

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Bibliographic Details
Main Authors: Bettina Trinschek, Felix Luessi, Jürgen Haas, Brigitte Wildemann, Frauke Zipp, Heinz Wiendl, Christian Becker, Helmut Jonuleit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3796502?pdf=render

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http://europepmc.org/articles/PMC3796502?pdf=render

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