Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

Regulation of ubiquitin-proteasome system (UPS), which controls the turnover of short-lived proteins in eukaryotic cells, is critical in maintaining cellular proteostasis. Here we show that USP14, a major deubiquitinating enzyme that regulates the UPS, is a substrate of Akt, a serine/threonine-speci...

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Bibliographic Details
Main Authors: Daichao Xu, Bing Shan, Byung-Hoon Lee, Kezhou Zhu, Tao Zhang, Huawang Sun, Min Liu, Linyu Shi, Wei Liang, Lihui Qian, Juan Xiao, Lili Wang, Lifeng Pan, Daniel Finley, Junying Yuan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
USP14
Akt
ubiquitin-proteasome-system
global proteostasis
Online Access:https://elifesciences.org/articles/10510

Internet

https://elifesciences.org/articles/10510

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