Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections

Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections

Abstract Background A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural and functional changes in the central nervous system (CNS), resulting in long-term neurological sequelae. An improved understanding of the pathogenes...

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Bibliographic Details
Main Authors: Leonardo D’Aiuto, Jennifer Naciri, Nicholas Radio, Sesha Tekur, Dennis Clayton, Gerard Apodaca, Roberto Di Maio, Yun Zhi, Peter Dimitrion, Paolo Piazza, Matthew Demers, Joel Wood, Charleen Chu, Jason Callio, Lora McClain, Robert Yolken, James McNulty, Paul Kinchington, David Bloom, Vishwajit Nimgaonkar
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Stem Cell Research & Therapy
Subjects:
Human induced pluripotent stem cells (hiPSCs)
Three-dimensional (3D) neuronal cultures
Antiviral drug screening
Herpes simplex virus type 1 (HSV-1)
High content screening
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13287-018-0881-6

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http://link.springer.com/article/10.1186/s13287-018-0881-6

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