The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097, a novel inhibitor of gamma secretase, which is a...

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Bibliographic Details
Main Authors: Chanh Huynh, Laura Poliseno, Miguel F Segura, Ratna Medicherla, Adele Haimovic, Silvia Menendez, Shulian Shang, Anna Pavlick, Yongzhao Shao, Farbod Darvishian, John F Boylan, Iman Osman, Eva Hernando
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3182998?pdf=render

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http://europepmc.org/articles/PMC3182998?pdf=render

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