Synaptojanin2 Mutation Causes Progressive High-frequency Hearing Loss in Mice

Progressive hearing loss is very common in the human population but we know little about the underlying molecular mechanisms. Synaptojanin2 (Synj2) has been reported to be involved, as a mouse mutation led to a progressive increase in auditory thresholds with age. Synaptojanin2 is a phosphatidylinos...

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Bibliographic Details
Main Authors: Elisa Martelletti, Neil J. Ingham, Oliver Houston, Johanna C. Pass, Jing Chen, Walter Marcotti, Karen P. Steel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
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Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.561857/full