Glucocerebrosidase: Functions in and Beyond the Lysosome

Glucocerebrosidase: Functions in and Beyond the Lysosome

Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose. Inherited deficiency of GCase causes the lysosomal storage disorder named Gaucher disease (GD). In GCase-deficient GD patients t...

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Bibliographic Details
Main Authors: Daphne E.C. Boer, Jeroen van Smeden, Joke A. Bouwstra, Johannes M.F.G Aerts
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Clinical Medicine
Subjects:
glucocerebrosidase
lysosome
glucosylceramide
skin
gaucher disease
Online Access:https://www.mdpi.com/2077-0383/9/3/736

Internet

https://www.mdpi.com/2077-0383/9/3/736

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