Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.

HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP. CD4⁺ T cells are the main target of infection and pla...

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Bibliographic Details
Main Authors: Fabio E Leal, Lishomwa C Ndhlovu, Aaron M Hasenkrug, Fernanda R Bruno, Karina I Carvalho, Harry Wynn-Williams, Walter K Neto, Sabri S Sanabani, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3566991?pdf=render

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http://europepmc.org/articles/PMC3566991?pdf=render

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