Expansion in CD39⁺ CD4⁺ immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological complications.
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP. CD4⁺ T cells are the main target of infection and pla...
Main Authors: | Fabio E Leal, Lishomwa C Ndhlovu, Aaron M Hasenkrug, Fernanda R Bruno, Karina I Carvalho, Harry Wynn-Williams, Walter K Neto, Sabri S Sanabani, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC3566991?pdf=render |
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