Modeling and measuring signal relay in noisy directed migration of cell groups.

We develop a coarse-grained stochastic model for the influence of signal relay on the collective behavior of migrating Dictyostelium discoideum cells. In the experiment, cells display a range of collective migration patterns, including uncorrelated motion, formation of partially localized streams, a...

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Bibliographic Details
Main Authors: Can Guven, Erin Rericha, Edward Ott, Wolfgang Losert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3642071?pdf=render