Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells.

Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells.

The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at membrane phospholipids, all three proteins modulate eicosanoid production. We h...

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Bibliographic Details
Main Authors: Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, Sandra Moriceau, Maryvonne Baudouin-Legros, Franck Brouillard, Jesus Ayala-Sanmartin, Lhousseine Touqui, Marc Chanson, Aleksander Edelman, Mario Ollero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2760709?pdf=render

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http://europepmc.org/articles/PMC2760709?pdf=render

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