Mitochondrial Sequestration and Ca2+-Dependent Release of Cytosolic Zn2+ Loads in Cortical Neurons

The endogenous divalent cations, Ca2+ and Zn2+, are both highly toxic upon excessive glutamate triggered intracellular accumulation. Given apparent parallels in their neurotoxic mechanisms, the present study aimed to explore interactions between these cations, by examining effects of moderate intrac...

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Bibliographic Details
Main Authors: Stefano L. Sensi, Dien Ton-That, John H. Weiss
Format: Article
Language:English
Published: Elsevier 2002-07-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102904936