Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

Chemokines are essential mediators of cellular trafficking, interactions and tumor development. Though adoptive cell therapy (ACT) has been a tremendous success in the treatment of metastatic melanoma (MM), a major obstacle for successful ACT, is limited homing of effector T cells to immune suppress...

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Bibliographic Details
Main Authors: Manja Idorn, Maria Olsen, Hólmfrídur Rósa Halldórsdóttir, Signe Koggersbøl Skadborg, Magnus Pedersen, Claus Høgdall, Estrid Høgdall, Özcan Met, Per thor Straten
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
ascites
act
chemokine receptor
cxcr2
adoptive cell therapy
genetic engineering
ovarian cancer
tumor homing
treg
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1412029

Internet

http://dx.doi.org/10.1080/2162402X.2017.1412029

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