Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons

Striatal dysfunction plays an important role in dystonia, but the striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate that conditional deletion of the DYT1 dystonia protein torsinA in embryonic progenitors of forebrain cholinergic and GABAergic neurons causes...

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Bibliographic Details
Main Authors: Samuel S Pappas, Katherine Darr, Sandra M Holley, Carlos Cepeda, Omar S Mabrouk, Jenny-Marie T Wong, Tessa M LeWitt, Reema Paudel, Henry Houlden, Robert T Kennedy, Michael S Levine, William T Dauer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
dystonia
torsinA
cholinergic interneuron
striatum
neurodegeneration
neurogenetics
Online Access:https://elifesciences.org/articles/08352

Internet

https://elifesciences.org/articles/08352

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