Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons
Striatal dysfunction plays an important role in dystonia, but the striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate that conditional deletion of the DYT1 dystonia protein torsinA in embryonic progenitors of forebrain cholinergic and GABAergic neurons causes...
Main Authors: | Samuel S Pappas, Katherine Darr, Sandra M Holley, Carlos Cepeda, Omar S Mabrouk, Jenny-Marie T Wong, Tessa M LeWitt, Reema Paudel, Henry Houlden, Robert T Kennedy, Michael S Levine, William T Dauer |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/08352 |
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