A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus

A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus

AimsCausal transcripts at genomic loci associated with type 2 diabetes (T2D) are mostly unknown. The chr8p23.1 variant rs4841132, associated with an insulin-resistant diabetes risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, LOC157273, located 175 kilobases from PPP1R3...

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Bibliographic Details
Main Authors: Alisa K. Manning, Anton Scott Goustin, Erica L. Kleinbrink, Pattaraporn Thepsuwan, Juan Cai, Donghong Ju, Aaron Leong, Miriam S. Udler, James Bentley Brown, Mark O. Goodarzi, Jerome I. Rotter, Robert Sladek, James B. Meigs, Leonard Lipovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
insulin resistance
hepatic glycogen storage
long non-coding RNA
metabolism
type 2 diabetes
regulatory mechanisms
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00615/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00615/full

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