The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, the authors show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-depen...

Full description

Bibliographic Details
Main Authors: Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15163-6

Internet

https://doi.org/10.1038/s41467-020-15163-6

Similar Items