A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

A Novel Tool for the Generation of Conditional Knockouts To Study Gene Function across the Plasmodium falciparum Life Cycle

One of the major limitations in studying P. falciparum is that so far only asexual stages are amenable to rapid conditional genetic modification. The most promising drug targets and vaccine candidates, however, have been refractory to genetic modification because they are essential during the blood...

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Bibliographic Details
Main Authors: Marta Tibúrcio, Annie S. P. Yang, Kazuhide Yahata, Pablo Suárez-Cortés, Hugo Belda, Sebastian Baumgarten, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Youri van Waardenburg, Elena A. Levashina, Robert W. Sauerwein, Moritz Treeck
Format: Article
Language:English
Published: American Society for Microbiology 2019-09-01
Series:mBio
Subjects:
plasmodium falciparum
malaria
molecular methods
reverse genetic analysis
Online Access:https://doi.org/10.1128/mBio.01170-19

Internet

https://doi.org/10.1128/mBio.01170-19

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