Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

Abstract Background As one of the major treatment obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), relapse of Ph+ALL may result from the persistence of leukemia-propagating cells (LPCs). Research using a xenograft mouse assay recently determined that LPCs were enr...

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Bibliographic Details
Main Authors: Yuan Kong, Yi-Lin Wu, Yang Song, Min-Min Shi, Xie-Na Cao, Hong-Yan Zhao, Ya-Zhen Qin, Yue-Yun Lai, Hao Jiang, Qian Jiang, Xiao-Jun Huang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Translational Medicine
Subjects:
Acute lymphoblastic leukemia
Ph-chromosome
Leukemia-propagating cells
Nilotinib
Ruxolitinib
Online Access:http://link.springer.com/article/10.1186/s12967-017-1286-5

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http://link.springer.com/article/10.1186/s12967-017-1286-5

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