Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin.

The genes encoding nuclear receptors comprise multiple 5'untranslated exons, which give rise to several transcripts encoding the same protein, allowing tissue-specific regulation of expression. Both human and mouse peroxisome proliferator activated receptor (PPAR) α genes have multiple promoter...

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Bibliographic Details
Main Authors: Emma S Garratt, Mark H Vickers, Peter D Gluckman, Mark A Hanson, Graham C Burdge, Karen A Lillycrop
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3692471?pdf=render