Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner

Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner

Background: Disturbance of immunometabolic signaling is a key process involved in the progression of obesity. Microglia—the resident immune cells in the brain, initiate local immune responses. It is known that hypercaloric diets lead to microglial activation. Previously, we observed that hypothalami...

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Bibliographic Details
Main Authors: Irina V. Milanova, Martin J. T. Kalsbeek, Xiao-Lan Wang, Nikita L. Korpel, Dirk Jan Stenvers, Samantha E. C. Wolff, Paul de Goede, Annemieke C. Heijboer, Eric Fliers, Susanne E. la Fleur, Andries Kalsbeek, Chun-Xia Yi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
microglia
immunometabolism
neuroinflammation
diet-induced obesity
high-fat diet
daily rhythms
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00424/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00424/full

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