Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

<p>Abstract</p> <p>Background</p> <p>Only a minority of cancer patients benefits from the combination of EGFR-inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A potential resistance mechanism is activation of EGFR and/or downstream pathways...

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Bibliographic Details
Main Authors: Stegeman Hanneke, Kaanders Johannes H, Wheeler Deric L, van der Kogel Albert J, Verheijen Marieke M, Waaijer Stijn J, Iida Mari, Grénman Reidar, Span Paul N, Bussink Johan
Format: Article
Language:English
Published: BMC 2012-10-01
Series:BMC Cancer
Subjects:
Head and neck cancer
Tumor microenvironment
Hypoxia
pAKT
EGFR
Online Access:http://www.biomedcentral.com/1471-2407/12/463

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http://www.biomedcentral.com/1471-2407/12/463

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