Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice

Efficient Distribution of a Novel Zirconium-89 Labeled Anti-cd20 Antibody Following Subcutaneous and Intravenous Administration in Control and Experimental Autoimmune Encephalomyelitis-Variant Mice

Objective: To investigate the imaging and biodistribution of a novel zirconium-89 (89Zr)-labeled mouse anti-cd20 monoclonal antibody (mAb) in control and experimental autoimmune encephalomyelitis (EAE) mice following subcutaneous (s. c.) and intravenous (i.v.) administration.Background: Anti-cd20-me...

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Bibliographic Details
Main Authors: Mary-Anne Migotto, Karine Mardon, Jacqueline Orian, Gisbert Weckbecker, Rainer Kneuer, Rajiv Bhalla, David C. Reutens
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
radiolabeling
positron emission tomography imaging
monoclonal antibody
neuroimaging
biodistribution
experimental autoimmune encephalomyelitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02437/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02437/full

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