Early-Stage Ocular Hypertension Alters Retinal Ganglion Cell Synaptic Transmission in the Visual Thalamus

Early-Stage Ocular Hypertension Alters Retinal Ganglion Cell Synaptic Transmission in the Visual Thalamus

Axonopathy is a hallmark of many neurodegenerative diseases including glaucoma, where elevated intraocular pressure (ocular hypertension, OHT) stresses retinal ganglion cell (RGC) axons as they exit the eye and form the optic nerve. OHT causes early changes in the optic nerve such as axon atrophy, t...

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Bibliographic Details
Main Authors: Ashish Bhandari, Jennie C. Smith, Yang Zhang, Aaron A. Jensen, Lisa Reid, Toni Goeser, Shan Fan, Deepta Ghate, Matthew J. Van Hook
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glaucoma
ocular hypertension
lateral geniculate nucleus
retinal ganglion cell
electrophysiology
synapse
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00426/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00426/full

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