SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion

Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism that medicated inflammatory response during ischemia and reperfusion (I/R...

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Bibliographic Details
Main Authors: Ying Han, Weiju Sun, Di Ren, Jingwen Zhang, Zhibin He, Julia Fedorova, Xiaodong Sun, Fang Han, Ji Li
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Redox Biology
Subjects:
SIRT1 agonist
NLRP3 inflammasome
ROS
Ischemia/reperfusion
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720303359

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http://www.sciencedirect.com/science/article/pii/S2213231720303359

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