MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation

MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation

Summary: MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic inflammation (wound response) is augmented in miR-223-deficient zebrafish, due primarily to elevated activation of the canonical...

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Bibliographic Details
Main Authors: Wenqing Zhou, Arpita S. Pal, Alan Yi-Hui Hsu, Theodore Gurol, Xiaoguang Zhu, Sara E. Wirbisky-Hershberger, Jennifer L. Freeman, Andrea L. Kasinski, Qing Deng
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
microRNA
miR-223
inflammation
neutrophils
NF-κB
epithelium
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301074

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http://www.sciencedirect.com/science/article/pii/S2211124718301074

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