Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease

Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease resulting in cognitive decline. A unique rat model, TgF344-AD, recapitulates pathological hallmarks of AD. We used a longitudinal design to address the timing of expression of behavioral phenotypes in male and female TgF344-AD rats....

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Bibliographic Details
Main Authors: Rachel Michelle Saré, Spencer K. Cooke, Leland Krych, Patricia M. Zerfas, Robert M. Cohen, Carolyn Beebe Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
amyloid-β
actigraphy
hyposmia
learning
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00601/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00601/full

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