The Hypothesis of “Embryonic Recall”: Mechanotransduction as Common Denominator Linking Normal Cardiogenesis to Recovery in Adult Failing Hearts

The Hypothesis of “Embryonic Recall”: Mechanotransduction as Common Denominator Linking Normal Cardiogenesis to Recovery in Adult Failing Hearts

Cardiac regeneration remains a clinical target regardless of numerous therapeutic concepts. We formulated a hypothesis claiming that periodic coronary venous pressure elevation (PICSO; Pressure controlled Intermittent Coronary Sinus Occlusion) initiates embedded, but dormant developmental processes...

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Bibliographic Details
Main Authors: Werner Mohl, Dejan Milasinovic, Thomas Aschacher, Alem Jusic, Abudunaibi Maimaitiaili, Frank Rattay
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
cardiac regeneration
systems biology
cardiac veins
cardiac development
PICSO
Online Access:http://www.mdpi.com/2308-3425/1/1/73

Internet

http://www.mdpi.com/2308-3425/1/1/73

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