Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal

Distinct Stromal Cell Factor Combinations Can Separately Control Hematopoietic Stem Cell Survival, Proliferation, and Self-Renewal

Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur i...

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Bibliographic Details
Main Authors: Stefan Wohrer, David J.H.F. Knapp, Michael R. Copley, Claudia Benz, David G. Kent, Keegan Rowe, Sonja Babovic, Heidi Mader, Robert A.J. Oostendorp, Connie J. Eaves
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003891

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http://www.sciencedirect.com/science/article/pii/S2211124714003891

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