The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy

The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy

Exposure of Neospora caninum tachyzoites to BKI-1294 in vitro results in the formation of long-lived multinucleated complexes (MNCs). However, in vivo treatment of BALB/c mice with BKI-1294 shortly after N. caninum infection during pregnancy was safe and profoundly reduced pup mortality and vertical...

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Bibliographic Details
Main Authors: Pablo Winzer, Dennis Imhof, Nicoleta Anghel, Dominic Ritler, Joachim Müller, Ghalia Boubaker, Adriana Aguado-Martinez, Luis-Miguel Ortega-Mora, Kayode K. Ojo, Wesley C. VanVoorhis, Andrew Hemphill
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Veterinary Science
Subjects:
neosporosis
mouse model
bumped kinase inhibitor
calcium-dependent protein kinase
immune response
live-vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.587570/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2020.587570/full

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