Oxidative stress activates the TRPM2-Ca2+-NLRP3 axis to promote PM2.5-induced lung injury of mice

Oxidative stress activates the TRPM2-Ca2+-NLRP3 axis to promote PM2.5-induced lung injury of mice

PM2.5, a main particulate air pollutant, poses a serious hazard to human health. The exposure to PM2.5 increases mortality and morbidity of many respiratory diseases such as asthma, chronic obstructive pulmonary diseases and even lung cancer. The contribution of reactive oxygen species (ROS) in the...

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Bibliographic Details
Main Authors: Chunyuan Wang, Xianzong Meng, Meiling Meng, Min Shi, Wenping Sun, Xiaojing Li, Xiao Zhang, Ruihao Liu, Ying Fu, Laiyu Song
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
PM2.5
Lung injury
ROS
TRPM2
NLRP3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220306740

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http://www.sciencedirect.com/science/article/pii/S0753332220306740

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