miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1.

miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1.

The lining of the adult heart contains epicardial mesothelial cells (EMCs) that have the potential to undergo fibrogenic Epithelial-to-Mesenchymal Transition (EMT) during cardiac injury. EMT of EMCs has therefore been suggested to contribute to the heterogeneous fibroblast pool that mediates cardiac...

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Bibliographic Details
Main Authors: Hasse Brønnum, Ditte C Andersen, Mikael Schneider, Maria B Sandberg, Tilde Eskildsen, Solveig B Nielsen, Raghu Kalluri, Søren P Sheikh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3575372?pdf=render

Internet

http://europepmc.org/articles/PMC3575372?pdf=render

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