Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links.

Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links.

The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of da...

Full description

Bibliographic Details
Main Authors: Debadeep Bhattacharyya, Srinivas Ramachandran, Shantanu Sharma, Wimal Pathmasiri, Candice L King, Irene Baskerville-Abraham, Gunnar Boysen, James A Swenberg, Sharon L Campbell, Nikolay V Dokholyan, Stephen G Chaney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3154474?pdf=render

Internet

http://europepmc.org/articles/PMC3154474?pdf=render

Similar Items