Targeted gene deletion of miRNAs in mice by TALEN system.

Targeted gene deletion of miRNAs in mice by TALEN system.

Mice are among the most valuable model animal species with an enormous amount of heritage in genetic modification studies. However, targeting genes in mice is sometimes difficult, especially for small genes, such as microRNAs (miRNAs) and targeting genes in repeat sequences. Here we optimized the ap...

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Bibliographic Details
Main Authors: Shuji Takada, Tempei Sato, Yoshiaki Ito, Satoshi Yamashita, Tomoko Kato, Miyuri Kawasumi, Masami Kanai-Azuma, Arisa Igarashi, Tomomi Kato, Moe Tamano, Hiroshi Asahara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797721?pdf=render

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http://europepmc.org/articles/PMC3797721?pdf=render

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