(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis. (-)-Englerin A (EA), an extract from the East African plant <i>Phyllanthus engleri</i> has been identified as a TRPC4/5 agonist. Here, we studied wh...

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Bibliographic Details
Main Authors: João de Sousa Valente, Khadija M Alawi, Sabah Bharde, Ali A. Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D. Brain
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
(-)-Englerin A
TRPC5
TRPC4
carrageenan
inflammation
synovitis
Online Access:https://www.mdpi.com/1422-0067/22/12/6380

Internet

https://www.mdpi.com/1422-0067/22/12/6380

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