Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups

Computational Treatment Simulations to Assess the Need for Personalized Tamoxifen Dosing in Breast Cancer Patients of Different Biogeographical Groups

Tamoxifen is used worldwide to treat estrogen receptor-positive breast cancer. It is extensively metabolized, and minimum steady-state concentrations of its metabolite endoxifen (C<sub>SS,min ENDX</sub>) >5.97 ng/mL have been associated with favorable outcome. Endoxifen formation is m...

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Bibliographic Details
Main Authors: Anna Mueller-Schoell, Robin Michelet, Lena Klopp-Schulze, Madelé van Dyk, Thomas E. Mürdter, Matthias Schwab, Markus Joerger, Wilhelm Huisinga, Gerd Mikus, Charlotte Kloft
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
tamoxifen
breast cancer
CYP2D6
polymorphism
genotype
individualized dosing
Online Access:https://www.mdpi.com/2072-6694/13/10/2432

Internet

https://www.mdpi.com/2072-6694/13/10/2432

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